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Lamp-2b外泌体

TīmeklisLysosome Associated Membrane Protein 2 LAMP2 (Danon) disease is a rare X-linked dominant, lysosomal disease caused by primary deficiency of LAMP2 gene that typically presents with cardiomyopathy, skeletal myopathy, and mental retardation. From: Heart Failure in the Child and Young Adult, 2024 View all Topics Add to … Tīmeklis2024. gada 26. marts · is speci c, a ordable and allows multiplexing with other SARS-CoV-2 LAMP primer sets. Introduction SARS-CoV-2 virus was rst detected in December of 2024 and rapidly spread throughout the world. To date, ... (Figure 2B). Due to the dual beacon design, the S6970 assay gives a clear readout of either WT SARS-CoV-2 …

【综述】Theranostics：工程化外泌体用于药物靶向递送 - 外泌体 …

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysosome-associated membrane glycoprotein 2 Skatīt vairāk Tīmeklis外泌体的靶向递送装置中：lamp-2b是一种常用于展示靶向基序的外泌体表面蛋白。 LAMP-2B是溶酶体相关膜蛋白(LAMP)家族的成员，在细胞内主要定位于溶酶体和内 … earthquake protection buildings https://almadinacorp.com

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes ...

Tīmeklis2024. gada 29. aug. · In this study, enhanced expression of human LAMP-2C in melanoma cells perturbed macroautophagy and chaperone-mediated autophagy in several human melanoma lines. In vitro analysis showed increasing LAMP-2C expression in a melanoma cell line, triggered reduced cellular LAMP-2A and LAMP … TīmeklisRemarkably, LAMP-2B functions independently of syntaxin 17 (STX17), a protein that is essential for autophagosome–lysosome fusion in non-CMs. Instead, LAMP-2B interacts with autophagy related 14 (ATG14) and vesicle-associated membrane protein 8 (VAMP8) through its C-terminal coiled coil domain (CCD) to promote autophagic fusion. Tīmeklis2014. gada 19. dec. · LAMP-2A is a transmembrane protein component for protein translocation to the lysosome. Here we present a study of the structure and dynamics of the transmembrane domain of human LAMP-2A in n-dodecylphosphocholine micelles by nuclear magnetic resonance (NMR). We showed that LAMP-2A exists as a … ct mr hartberg

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes ...

Category:工程化外泌体——药物递送专家&外泌体研究利器 - 知乎

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Lamp-2b外泌体

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes ...

TīmeklisLAMP-2A and LAMP-2B are constitutively expressed in most tissues and cells, whereas high expression of LAMP-2C is limited to the brain, heart, skeletal muscle, small intestine, and colon (20 ... TīmeklisAnti-LAMP2A antibody [EPR4207 (2)] - Lysosome Marker (ab125068) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation.

Lamp-2b外泌体

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TīmeklisThere are three LAMP-2 isoforms, LAMP-2A, -2B, and -2C. Clinical features of Danon disease are thought to be mediated by loss of the LAMP-2B isoform which is the major isoform expressed in muscle. Tīmeklis将生物活性分子负载到外泌体中可提高生物活性分子体内稳定性、血液循环时间和细胞靶向效率。 运用与外泌体膜蛋白LAMP-2B/CD63融合表达的技术方法，恩泽康泰构建 …

TīmeklisThese data demonstrate the potential of using LAMP-based endolysosomal trafficking as a means to augment the generation of polyfunctional, antigen-specific T cells in …

TīmeklisLAMP2 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 410 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Align Add a publication Entry feedback Function TīmeklisAddgene Alerts. Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description lysosomal associated membrane protein 2. Also known as CD107b, DND, LAMP-2, LAMPB, LGP-96, LGP110. Species Homo sapiens. Entrez ID 3920. MGC ID BC002965.

TīmeklisDanon Disease. Danon disease (previously known as GSD IIb, or pseudo Pompe disease with normal GAA activity) is an X-linked recessive lysosomal glycogen …

Tīmeklis什么是LAMP？ 环介导等温扩增 (Loop-mediated isothermal amplification， LAMP )是Notomi等人于2000年提出来的一种新的核酸扩增技术。 针对靶基因的6个区域设计4种特异引物，在链置换DNA聚合酶 (Bst DNA polymerase)作用下，可以在60-65℃温度范围内进行恒温扩增。 在扩增的初始阶段，由于引物的延伸和初级扩增子的连续链置换， … earthquake protection systems epsTīmeklis2024. gada 24. dec. · Here, we identify the LAMP-2 isoform B (LAMP-2B) as required for autophagosome–lysosome fusion in human cardiomyocytes (CMs). Remarkably, … ctmrisociety.orgTīmeklis2B knockout and Danon hiPSC-CMs, we conclude that LAMP-2B deficiency is sufficient and necessary to cause the phenotypes observed in Danon CMs. Our findings thus provide insights into the nature of autophagy in human CMs and Danon pathogenesis. Results LAMP-2B Is the Predominant LAMP-2 Isoform Expressed in Human and … ctmr meaningTīmeklis利用携带软骨细胞的亲合肽（CAP）融合表达展示于外泌体膜蛋白（lamp2b）上表面作为靶向的基因工程化外泌体可实现靶向软骨细胞（图1）。 与无靶向的天然外泌体相 … ctm riorgesTīmeklischicken and mouse LAMP-2b and LAMP-2c isoforms should be switched and unified with the current human nomenclature. To avoid confusion with the already pub-lished papers, we further suggest using capital letters (A, B, and C) instead of the small letters (a, b, and c) for the LAMP-2 isoforms (Figure 2B). Lysosome-associated ctmrp.netTīmeklis2024. gada 9. febr. · 外泌体的生物发生、分泌和细胞进入 外泌体的结构和组成 通过遗传/生物操作或化学修饰的外泌体表面工程化 人和小鼠lamp-2b的蛋白结构域 外泌体的 … ctmrr-400TīmeklisSignificantly, vaccination with HER2-LAMP produced tumor regression in ~30% of vaccinated mice with established tumors in an endogenous model of metastatic HER2+ BC, compared with 0% of HER2-WT vaccinated mice. This therapeutic benefit is associated with enhanced tumor infiltration of activated CD4+ and CD8+ T cells. ctmr meaning spanish