Dynein light intermediate chain binding

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August undefined, 2024

WebIn both complexes, the heavy chain (HC) subunits hydrolyze ATP and interact with microtubules to generate force. The N-termini of the dynein HCs act as scaffolds for the accessory proteins, which include the dynein intermediate chain (IC), the dynein light-intermediate chains (LICs), and the dynein light chains (LCs) [1]. WebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J Biol Chem. 2005; 280:8172–8179. [Google Scholar] Lo KW, Naisbitt S, Fan JS, Sheng M, …

Roles of the multivalent dynein adaptors BicD2 and RILP in neurons

WebMay 20, 2024 · Adaptor binding is governed by the homologous dynein light intermediate chain subunits LIC1 (DYNC1LI1) and LIC2 (DYNC1LI2), which exist in mutually … WebJan 1, 2024 · The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proc. Natl. Acad. Sci. U.S.A., 104 (2007), ... The … how does the market work in rise of ruins

Distinct roles for dynein light intermediate chains in …

WebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by … WebOct 1, 2014 · Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor heavy chain, from a thermophilic fungus. We show that … WebFeb 5, 2008 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: minus-end-directed microtubule motor activity Source:GO_Central. ... The dynein complex consists of at least two heavy chains and a number of intermediate and light chains. By similarity. Protein-protein interaction databases. BioGRID. 108107 9 ... photocommonsdk是什么文件夹可以删除吗

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Analysis of the Dynein-Dynactin Interaction In Vitro and In Vivo

Webically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components of the dynein motor complex, which includes the heavy chains (530 kDa), the light intermediate chains (52–61 kDa), the p150glued subunit of dynactin, and the light ... Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… photocns chinanews.com.cnWeb13411 Ensembl ENSG00000105877 ENSMUSG00000018581 UniProt Q96DT5 n/a RefSeq (mRNA) NM_001277115 NM_010060 RefSeq (protein) NP_001264044 n/a Location (UCSC) Chr 7: 21.54 – 21.9 Mb Chr 12: 117.84 – 118.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dynein axonemal heavy chain 11 (DNAH11), is a … photoclub normandie

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Dynein light intermediate chain binding

WebJun 1, 2002 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: microtubule motor activity Source:UniProtKB. 1 publication. ... Consists of at least two heavy chains and a number of intermediate and light chains. Protein-protein interaction databases. BioGRID. 120722 7 interactors; IntAct. Q8TD57 6 … WebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690-2701. DOI: 10.1091/mbc.e11-01-0075. ... The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National ...

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WebAug 30, 2024 · Further, we noticed that the N-terminus of kazrin C shares homology with dynein/dynactin adaptors and that it directly interacts with the dynactin complex and the dynein Light Intermediate Chain 1 (LIC1). Altogether, the data indicate that one of the primary kazrin functions is to facilitate endocytic recycling via the perinuclear endocytic ... WebPhosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions ... Dynein Light Intermediate Chains as …

Webdata:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAKAAAAB4CAYAAAB1ovlvAAAAAXNSR0IArs4c6QAAAw5JREFUeF7t181pWwEUhNFnF+MK1IjXrsJtWVu7HbsNa6VAICGb/EwYPCCOtrrci8774KG76 ... WebSpindly’s N-terminal coiled-coil uses distinct motifs to bind dynein light intermediate chain and the pointed-end complex of dynactin. Mutations in these motifs inhibit assembly of a dynein–dynactin–Spindly complex, and a null mutant of the dynactin pointed-end subunit p27 prevents kinetochore recruitment of dynein–dynactin without ...

WebHomodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), … WebJan 27, 2006 · Human and mouse cytoplasmic dynein subunit genes. The subunits of the cytoplasmic dynein complexes are resolved into subunit polypeptides of ~530 kDa (heavy chains), ~74 kDa (intermediate chains), ~33–59 kDa (light intermediate chains), and ~10–14 kDa (light chains) in SDS-PAGE gels (Figure 1A).Research on the cytoplasmic …

WebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to …

Webically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components … photocoachWebAug 26, 2024 · Binding of one dynein-2 complex to the train creates extra binding ... Hou, Y., Pazour, G. J. & Witman, G. B. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar ... photoco central marketWebShop Target Dulles Store for furniture, electronics, clothing, groceries, home goods and more at prices you will love. photoco photoshare pl 7 manualWebMay 1, 2024 · Presumably to accommodate its very broad range of activities, a variety of dynein “cargo”-binding mechanisms have evolved. In some cases, dynein-cargo associations are mediated directly by the cytoplasmic dynein intermediate or light intermediate chain subunits [[2], [3], [4]]. how does the marketing department workWebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated … how does the market work in australiaWebMar 30, 2024 · The light-intermediate chain has a Ras-like fold and appears to bind to nucleotides (Schroeder et al., 2014; Toropova et al., 2024). Although nucleotide-binding by the light-intermediate chain does not seem essential for dynein-2 function (Hou et al., 2004), whether it serves a structural role or has a minor regulatory function remains unclear. photocoagulator laser systemWebThe dynein light intermediate chain . 2. The dynein accessory proteins Lis1, Nde and Ndel-1 . This will be achieved by studying and manipulating dynein and accessory protein activity using in vitro motility assays and living tissue culture cells. Importantly, we will also investigate the role of how does the marriage tax allowance work