WebThe efficient, simultaneous synthesis of structurally diverse compounds, better known as diversity-oriented synthesis (DOS), is not obvious, and remains a challenge to synthetic chemistry. This personal … WebSince our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space and …
Diversity-oriented synthesis of marine sponge derived …
Diversity oriented synthesis or DOS is a strategy for quick access to molecule libraries with an emphasis on skeletal diversity. In one such application a Petasis reaction product (1) is functionalized with propargyl bromide leading to a starting compound (2) having 5 functional groups. This molecule can be subjected to a range of reagents yielding unique molecular skeletons in one generation. WebDiversity-Oriented Synthesis of Chemically Recyclable Poly(sulfonamide ester)s through Organocatalytic Aziridine-Based Multicomponent Polymerization . Songjie Fan, Peng Zhu, Jintong Ye, Huishan Huang, Zhen Zhang and Jinxiang Dong Abstract. Aziridine is a highly reactive strained ring that allows the synthesis of diverse small molecules. ... botes interiors
The Basics of Diversity-Oriented Synthesis
WebMar 7, 2011 · Diversity-oriented synthesis (DOS) is an approach toward small-molecule library synthesis, which seeks to achieve this goal (9, 10, 13, 27). The overall aim of a … Webinteracting with preselected protein targets [called target-oriented synthesis (TOS)] and those libraries used in “efforts to identify simultaneously therapeutic protein Diversity … WebDiversity-Oriented Synthesis represents the synthesis of relatively small libraries of organic molecules that are structurally more complex, have a greater variety of core structures, and possess richer stereochemical variations than those produced by traditional combinatorial chemistry. hawthorne housing co-op